Arsenal are hoping to sign Pablo Mari on a permanent basis (Picture: Getty)Arsenal are, however, likely to find it hard to raise the necessary funds to sign Upamecano, especially in light of the financial ramifications of the COVID-19 pandemic which prompted the club to request the playing and coaching staff take a 12.5% pay cut.AdvertisementAdvertisementUpemecano, meanwhile, will reportedly only move to a club where he has a strong possibility of regular first team football.More: Arsenal FCArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira movesThomas Partey debut? Ian Wright picks his Arsenal starting XI vs Manchester CityArsene Wenger explains why Mikel Arteta is ‘lucky’ to be managing ArsenalBoth Manchester clubs, as well as Spanish giants Real Madrid and Barcelona are keeping tabs on his sitatuation but Bayern Munich are so far the only club to have made a formal approach. The Bundesliga leaders look set to lose long-serving stalwart Jerome Boateng in the summer, while Upamecano is represented by German agency SportsTotal, who also have Toni Kroos on their books, which could prove pivotal with regard to the defender’s future.MORE: Manchester United move ahead of Arsenal in transfer race for Dayot UpamecanoMORE: Manchester United ready to hijack Arsenal’s move for Dayot UpamecanoRead the latest updates: Coronavirus news live Advertisement Metro Sport ReporterWednesday 22 Apr 2020 10:11 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link Comment Bayern Munich make first move for Arsenal transfer target Dayot Upamecano Arsenal are among several high-profile European clubs tracking Dayot Upamecano (Picture: Getty)Bayern Munich have registered concrete interest in Arsenal transfer target Dayot Upamecano.The highly sought after France international defender is destined to leave Red Bull Leipzig this summer for a fee of €60m.According to L’Équipe, the 21-year-old is yet to decide his next destination but a host of Europe’s biggest clubs are said to be monitoring his situation. Arsenal were reported to have made a bid last summer but instead spent the majority of their transfer budget on Ivory Coast international winger Nicolas Pepe. ADVERTISEMENTThe Gunners have shown defensive improvement under new head coach Mikel Arteta and are hopeful of making Pablo Mari’s loan move from Flamengo permanent in the summer. Advertisement
Greensburg, In. — Napoleon State Bank CEO/President Mark Comer says the first steps toward the improved Greensburg branch are underway. “The demolition of the old Burger Chef building is the first visual sign the beginning of this project. Our decision to open a second location in the Greensburg market is an important step towards meeting the needs of our growing customer base in that area,” Mark Comer, CEO/President said. “The new Lincoln Street location will offer more convenience to customers in a different part of town and will provide opportunities for growth for our locally owned community bank.”Pending regulatory approval, construction operations for the fifth location are set to begin in mid-2018. Officials say a sixth location in Westport is planned for early 2019.The bank has been locally owned since 1903 and serves Ripley and Decatur Counties.
Observations by the Spitzer Space Telescope, announced in a JPL press release, “pose a challenge to existing theories of giant planet formation, especially those in which planets build up gradually over millions of years.” Three young stars show clearings in dust disks surrounding them, suggesting that gas giant planets inhabit the clearings and must have been formed in a million years or less. Instead of growing slowly like giant redwoods, these new planets must have sprung up quickly like wildflowers, the report describes. This is an update on the 10/18/2004 findings from Spitzer. See also Science Daily and Space.com.OK, now that we know that planets can form in far less time than textbooks have claimed for centuries, can we finally ditch the mythical age of our solar system? Can we entertain the notion that many phenomena in our solar system look young, because they actually are? (See 08/30/2005, 09/06/2005, 06/30/2005, 03/22/2005, 03/11/2005, 06/05/2003 and other chain links on Dating Methods). The only one who needed the billions of years was Charlie, and he’s dead.(Visited 5 times, 1 visits today)FacebookTwitterPinterestSave分享0
Some words in English have alternate spellings, but sound the same. If the sound is the same, how would a recording device tell them apart? Would it make any difference? It shouldn’t, but now scientists are realizing that genetic codons spelled differently can influence the protein formed – even when the spellings, called “synonymous codons”, produce the same amino acid when translated. Suppose you are a prompter at a spelling bee. You read the word “aneurysm” aloud as the next word to be spelled. One student spells ANEURYSM, the next spells it ANEURISM. Since both forms are acceptable according to the dictionary (though the first is more common) each student should be graded as correct. But imagine that the judge, listening to the second spelling and not as familiar with it, has to check the dictionary before announcing her decision. Now suppose that the slight time delay affects what a reporter has time to write before rushing his story to the press. The resulting story could differ substantially, even though both spellings are, for all practical purposes, equivalent. Something like that happens in the genetic code, according to researchers at the University of Pennsylvania, publishing in Science.1 There are 64 possible triplet codons in the DNA code (table), but only 20 amino acids they produce (chart). As one can see, some amino acids can be coded by up to six “synonyms” of triplet codons: e.g., the codes AGA, AGG, CGA, CGC, CGG, and CGU will all yield arginine when translated by the ribosome. If the same amino acid results, what difference could the synonymous codons make? The researchers found that alternate spellings might affect the timing of translation in the ribosome tunnel, and slight delays could influence how the polypeptide begins its folding. This, in turn, might affect what chemical tags get put onto the polypeptide in the post-translational process. In the case of actin, the protein that forms transport highways for muscle and other things, the researchers found that synonymous codons produced very different functional roles for the “isoform” proteins that resulted in non-muscle cells – beta-actin progressing to the sites of cell movement at the membrane, and gamma-actin staying in the interior, “in dense non-branched networks and long contractile stress fibers that impart morphological stability and support cell adhesion.” Though both forms got “arginylated” with an arginine tag after translation, the beta-form appeared to start folding earlier, producing a slightly different shape that affected other post-translational modifications, thus affecting its functional role in the cell. The gamma form also got tagged with ubiquitin, targeting it for earlier degradation in the proteasome. The authors proved that it was the different codon spellings that produced these changes by modifying the codons in both genes with their look-alike synonyms and watching the outcomes. Sure enough, the beta-actin gene produced a protein that acted like gamma-actin when spelled the gamma way, and the gamma-actin gene produced a beta-actin-like protein when spelled the beta way. The authors extended the principle they discovered to say, in conclusion, “This mechanism may be used not only with actin isoforms but also with other closely homologous but selectively arginylated proteins.” As a result, an alternate spelling difference in the DNA code can result in different functional outcomes for two isoforms of actin, even though their amino acid sequences are essentially identical (98%). This amounts to a new mechanism for regulation of the genome and proteome (the set of proteins in the cell). Ivana Weygand-Durasevic [U of Zagreb, Croatia] and Michael Ibba [Ohio State], commenting on this finding in the same issue of Science,2 recognized it as a fundamental discovery: “This is an unexpected example of proteins whose properties are determined at the nucleotide rather than the amino acid level, forcing a reassessment of what defines a synonymous change in a gene sequence.” In their conclusion, they repeated, “Whatever the exact mechanism, the discovery of Zhang et al. that synonymous codon changes can so profoundly change the role of a protein adds a new level of complexity to how we interpret the genetic code.” For other recently-discovered regulatory mechanisms in the genome and epigenetic factors affecting function, see 08/09/2010 bullet 2, 08/02/2010, 07/31/2010, 07/24/2010, and 06/24/2010, or search for the words regulation, gene expression, or epigenetic in the Search Bar.1. Zhang, Saha, Shabalina and Kashina, “Differential Arginylation of Actin Isoforms Is Regulated by Coding Sequence�Dependent Degradation,” Science, 17 September 2010: Vol. 329. no. 5998, pp. 1534-1537, DOI: 10.1126/science.1191701.2. Ivana Weygand-Durasevic and Michael Ibba, “Cell Biology: New Roles for Codon Usage,” Science, 17 September 2010: Vol. 329. no. 5998, pp. 1473-1474, DOI: 10.1126/science.1195567.The mismatch of 64 codons to 20 amino acids has struck some geneticists as wasteful. “Degenerate” is the term used to describe mismatched codes that do not show a one-to-one correspondence. The finding described above may change that view. Perhaps all those synonyms have functional purposes after all. If so, it suggests that synonymous mutations might be more destructive than thought, even though the same amino acid sequence is produced in translation, and even though there may be some tolerance to synonymous mutations (i.e., they might not result in the death of the organism). Design theorists might find some functional role for adaptation at the micro-evolutionary level (where no new genetic information is added) where synonymous mutations might be switched on by epigenetic factors from cues in the environment. There are several ways this finding can enlighten design thinking while causing new strains for evolutionary theory. The authors did not comment on how this regulatory system might have evolved, other than to state that the two forms of actin are “homologous,” or presumably descended from a common ancestral form. But that’s a circular argument for common descent, because it assumes that sequence similarity is evidence of common descent. It could be evidence of common design. An ancestral cell would need the two functions simultaneously: motility at the cell membrane, and network maintenance in the interior. Arguing that one evolved from the other begs the question of how the functions arose in the first place. Each “reassessment” of our knowledge of the genetic code leads to more functional complexity. That’s not evidence for evolution, but for intelligent design. (Visited 63 times, 1 visits today)FacebookTwitterPinterestSave分享0
Tags:#twitter#web Facebook is Becoming Less Personal and More Pro… Related Posts The Dos and Don’ts of Brand Awareness Videos Are you suspicious of those sexy avatars and “marketingbizpro” accounts following you on Twitter, but don’t have the time or inclination to block and report them one by one as they pop up?We’ve just found a new, completely free app that will zap those bots and bad users in just one click. It’s fully customizable, so you can tell the blocker what you personally consider to be a spam account. And you can choose to simply unfollow those users, block them or report the accounts to Twitter, as well – again all with just one click. StopTweet is definitely one of the more useful apps we’ve seen lately, and it also helps us all do our part to clean up the Twitter universe.We just tried it on an account and caught around 50 spam followers; pretty exciting, no? Here’s how it works. You tell StopTweet what behavior you think is spammy by defining a few important parameters. The first parameter is follower-to-friend ratios, which StopTweet considers on a scale of 1 to 100%. I personally think it’s sketchy when none of the people you follow have returned the favor. I like my friends to be engaged and engaging.Next, you tell StopTweet how many tweets you’d like your followers to have on a scale of zero to 30. This won’t work on the spambots that ping 500 people with the same “LOOK AT THIS CRAZY BRITNEY VIDEO!!1!”, but it’ll certainly get rid of inactive accounts and users who aren’t really adding much value to your network.It works for followers and friends, and you can take one of three actions (unfollow, block or report) on the account StopTweet finds. StopTweet also comes with three convenient presets for light, medium and aggressive scans. Guide to Performing Bulk Email Verification The app also has a tab to see your own list of spammer accounts, but we weren’t able to click through due to a possible bug in the very new app.“We didn’t like any of the applications that were already out there. They were all too complicated for the average Twitter user,” wrote creator Joi Company, which also created Twitstatus, a keyword-based Twitter widget generator. “The application is extremely easy to use, and allows you to only block who you want to block without hassle. On top of all this, it’s free. Most of the apps we found charge a monthly or yearly fee. We do not.”We think StopTweet is a genuinely useful app, and we recommend that you give it a shot and let us know how it works for you. jolie odell A Comprehensive Guide to a Content Audit
One of the companies behind what’s called a key technology inside the XBox Kinect motion-controller says it has struck a deal with PC maker Asus to bring a similar interface to PCs. Matt Rosoff of Business Insider reports this afternoon that the company, PrimeSense, will show off its product called Wavi Xtion at the Consumer Electronics Show this week.“The companies imagine it being used not for games, but for browsing multimedia content and accessing the Internet and social networks–basically, the main things consumers use their PCs for,” Rosoff writes. “There will also be APIs for third-party developers and a Wavi Xtion store where developers can sell motion-controlled apps.” The devices will reportedly work on all PCs, not just computers from Asus.It’s a little surprising that Microsoft didn’t get an exclusive license on the PrimeSense technology, but perhaps that would have required an acquisition one of the companies didn’t want to happen and perhaps there’s more to making Kinect what it is than PrimeSense would have us believe. APIs and an App Store sound quite intriguing, if trendy.The day the Kinect went on sale, we asked leading gaming and wireless analysts about the prospects of it, or something like it, going beyond gaming and into web connected devices around the home. They had varying estimations of the likelihood of that occurring.James McQuivey, Consumer Product Strategy analyst at Forrester, had written two weeks prior that, “Kinect is to multitouch user interfaces what the mouse was to DOS. It is a transformative change in the user experience, the interposition of a new and dramatically natural way to interact — not just with TV, not just with computers — but with every machine that we will conceive of in the future.” (Get Ready for Kinect to Completely Change Our Lives)McQuivey grew even more effusive in December, after smashing his hand through a lightbulb while swinging his arms around playing with his Kinect. “Kinect feels very, very real. When you play it, you have a tendency to lose your sense of space and placement in the real world…What will we call the new experiential medium that will result from natural user interfaces+3D+touch interfaces+augmented reality — technologies which are all conspiring in this decade to alter our lives? This part game, part narrative, part interactive, part video, potentially collaborative, experience-rich medium could, in 2020, be a $10 billion business. More interesting to me, who will be the Shakespeare, Cervantes, or Kurosawa of this new media? Or should I ask who will be the Bell, Edison, or Jobs of this new technology ecosystem?”25 days after its launch, the Kinect was outselling what was the world’s fastest-adopted consumer electronics device in history (the iPad) 2 to 1.A Kinect-type interface for all PCs? That sounds very, very hot – if it can be executed well.Russoff writes that the system will launch in the second quarter of this year. marshall kirkpatrick Top Reasons to Go With Managed WordPress Hosting Tags:#Internet of Things#web Related Posts A Web Developer’s New Best Friend is the AI Wai… Why Tech Companies Need Simpler Terms of Servic… 8 Best WordPress Hosting Solutions on the Market
This year’s defense authorization bill almost certainly won’t give DoD the green light it wants to hold a new BRAC round, but it could help the department build its case that a new round is needed.The House version of the annual defense policy bill calls for DoD to prepare a 20-year force structure plan for each service and an infrastructure assessment that could be used to determine the level of excess capacity. The Senate draft does not contain a similar provision, however, and so it is not yet clear if the House language will remain in the final bill.The fiscal 2016 authorization bill will be highlighted on Wednesday, June 24, when several members of the congressional Armed Services committees address the Defense Communities National Summit during the Congressional Keynote Briefing. One of the featured speakers will be Washington Rep. Adam Smith, the top Democrat on the House Armed Services Committee and one of the few lawmakers who has backed the Obama administration’s request for a new base closure round.Smith, however, has proposed a number of reforms to the base closure process to ensure that implementation costs for a new round are reasonable and that the recommendations yield significant savings within five years.Most recently the debate in Congress over the authorization bill has focused on the GOP strategy to rely on DoD’s war account to bypass the statutory spending caps. On Tuesday, the Senate rejected a Democratic effort to stop lawmakers from authorizing the use of tens of billions of dollars in extra war funds to bolster the Pentagon’s FY 2016 budget.Following the vote, it’s not clear whether Senate Democrats will try to block the annual policy bill, S. 1376, from advancing in the chamber. Afterwards, Democrats vowed to stop the GOP from going ahead with its strategy to offer the Pentagon budget relief by adding funds to its overseas contingency operations (OCO) account while ignoring domestic agencies by blocking progress on spending bills.“I don’t know what will happen,” Sen. Dick Durbin (D-Ill.) told reporters when asked whether Democrats would filibuster the bill if the vote failed. “I think I know what our plan is on appropriations; it’s not as clear on defense authorization,” he said, reported the Hill.Tuesday’s vote took up an amendment from Sen. Jack Reed (R.I.), ranking member on Senate Armed Services, which would have restricted the use of $38 billion added to the OCO account unless Congress lifted the discretionary spending caps on defense and non-defense spending. S. 1376 authorizes a total of $89 billion for the OCO account; the Obama administration had requested only $51 billion.“There are many good reforms in the NDAA but they are compromised by the inefficient, irresponsible OCO budget gimmick,” Reed said in a written statement. “Sending the president a bill to veto just leads to more government by crisis, and another partisan legislative cliff,” Reed added. Prior to the vote, John McCain (R-Ariz.), Senate Armed Services chair, urged senators not to make the authorization bill a “hostage” for a dispute over spending.“The NDAA is a policy bill. It can’t solve the Budget Control Act,” McCain said. “It deals only with defense issues, and it doesn’t spend a dollar.”The budget framework adopted by congressional Republicans for FY 2016 endorses the strategy of relying on the OCO account as a way of meeting the total dollar amount of the president’s budget request for DoD without adjusting the Budget Control Act limits. But Democrats in both chambers, along with the White House, have opposed the maneuver in a bid to bring the GOP to the negotiating table.“We shouldn’t wait to solve this problem. We need to get to the table now and work together to eliminate the threat of sequestration, just as every single military leader has asked us to do,” Reed said. Dan Cohen AUTHOR