ANAHEIM — It was going to take a miraculous turn of events to change what was almost a given, but it’s now set in stone — the A’s road to the ALDS will have to go through New York.The Yankees knocked off the Boston Red Sox 11-6 on Friday night, securing their position as the top American League wild-card team. The wild-card game will be played Wednesday at Yankee Stadium.Before the A’s took on the Angels on Friday, manager Bob Melvin said he along with pitching coach Scott Emerson and GM …
A new study appears to show that the bacterial flagellum, a molecular rotary motor that has become iconic of the intelligent design movement, can repair parts of its rotor while it is rotating. The results of the study by Oxford University were published in PNAS,1 and were also the focus of a Commentary in PNAS by Michael D. Manson of Texas A&M University.2 Previous studies had shown that parts of the stationary part (stator) could be replaced while the flagellum was in operation, but the rotor? “Turnover of a component of the rotor is even more surprising than stator turnover, given that it was previously known that the number of stator complexes can change while the motor is running,” the Oxford scientists said. The abstract explained:Most biological processes are performed by multiprotein complexes. Traditionally described as static entities, evidence is now emerging that their components can be highly dynamic, exchanging constantly with cellular pools…. It is powered by transmembrane ion flux through a ring of stator complexes that push on a central rotor. The Escherichia coli motor switches direction stochastically in response to binding of the response regulator CheY to the rotor switch component FliM. Much is known of the static motor structure, but we are just beginning to understand the dynamics of its individual components…. We show that the ~30 FliM molecules per motor exist in two discrete populations, one tightly associated with the motor and the other undergoing stochastic turnover…. In many ways the bacterial flagellar motor is as an archetype macromolecular assembly, and our results may have further implications for the functional relevance of protein turnover in other large molecular complexes.“The bacterial flagellar motor is one of the most complex biological nanomachines,” began the first sentence of their paper, edited by Howard Berg (Harvard), one of the pioneers of flagellum research. Using specialized imaging techniques, the Oxford team was able to identify components of the rotor complex undergoing dynamic turnover in about 30- to 40-second timeframes. This turnover may be due to maintenance of the motor, or it may have functional significance. It may be involved, for instance, in switching the rotation from normal counterclockwise runs to the occasional clockwise “tumbling” that bacteria undergo when following a chemical trail. In E. coli, which have four to eight flagella, it may be involved in synchronization of the flagella – they don’t yet know for sure. It appears that signaling from the environment is involved in the turnover, because a response regulator in the chemotaxis signal transduction response pathway “is also required for measurable FliM turnover to occur over the time scale of our experiments,” they said. Though not certain whether it is a trigger or a by-product of the switch from normal mode to tumbling mode, the association is compelling: “This work represents direct evidence for signal-dependent dynamic exchange of switch complex components in functioning flagellar motors, raising the possibility that turnover is involved in the signaling mechanism.” Michael Manson commented on the findings in PNAS,2 offering additional interesting details about the flagellum: “The flagellar motor was the first biological rotary device discovered” (Berg, 1973), he pointed out; “Flagella spin at several hundred to >1,000 revolutions per second in different bacteria.” He described the parts list and something about the torque and operation of the flagellum, and provided a cross-sectional diagram. “Filament growth decreases with length, and a broken filament can regenerate,” he continued. “Unfolded flagellin subunits diffuse through the hollow center of the filament and assemble at its distal tip. Filaments extend several cell lengths and are quite fragile; their dynamic nature is necessary. Each flagellar motor functions for the lifetime of its cell.” He described how protons flow through the Mot complexes (parts of the stator) and then couple to the rotor, and how these must be firmly anchored to the cell wall to endure the tremendous torques put on them by the rotor: “The high torque required to turn a flagellum under heavy load requires that Mot complexes attach firmly to the cell wall.” Even so, “Despite its anchoring, the stator is surprisingly dynamic.” Other studies show that the Mot protein parts also turnover rapidly – with a half-life of 30 seconds. As for the findings of the Oxford team, Manson said, “Parts exchange in the stator and rotor may just be routine maintenance, and the aggregates of 18 FliM molecules could be storage devices rather than assembly intermediates. The authors are suitably cautious about speculating whether FliM turnover is involved in the switch function of the C ring, emphasizing that the exchange of FliM subunits could be either a cause or effect of motor reversal.” But as he looked forward to additional exciting findings in this kind of research on flagella and other molecular machines, he paid his respects to this machine in particular: “Further studies of this type will undoubtedly lead to exciting new revelations about the inner workings of the elegant molecular machinery of the flagellar motor.”1. Delalez et al, “Signal-dependent turnover of the bacterial flagellar switch protein FliM,” Proceedings of the National Academy of Sciences, Published online before print May 24, 2010, doi: 10.1073/pnas.1000284107.2. Michael D. Manson, “Dynamic motors for bacterial flagella,” Commentary, Proceedings of the National Academy of Sciences, print June 11, 2010, doi: 10.1073/pnas.1006365107.Altogether now, shout the familiar refrain: “These authors said nothing about evolution!” If nothing in biology makes sense except in the black-light of ev-illusion, where was Mr. Darwin? Is that him in bed, sick to his stomach again? Go make him some intelligently designed chicken soup, and leave him be. The rest of us are excited about the union of engineering and biology in this clear case of machinery on the molecular scale. Now we have an example of possible maintenance during operation, and if not that, a functional operation that involves dynamic swapping of parts while a rotor is spinning at more than 60,000 rpm! The bacterium doesn’t need to go into a drydock; its repair squad can fix parts on the fly. Imagine what would be required to swap out the blades on an outboard motor while it is spinning. Furthermore, imagine having the process automated, with feedback from the environment. How would you even design such a thing? The flagellum has a constant flow of FliM parts into the system. Apparently, there is some sort of buffer store where parts can stand ready for use, and then something guides them into position. Manson’s oversimplified diagram shows a part attaching to a rotor blade, which might provide an attachment point for a FliM molecule to get replaced during a reversal of direction. However this occurs, it is bound to be exciting and amazing. Did you catch that dramatic understatement by Manson? “Parts exchange in the stator and rotor may just be routine maintenance, and the aggregates of 18… molecules could be storage devices….” What did he just say? Maintenance! Storage devices! This is bacteria we are talking about. This is life that lives in dirty water. That’s like walking by a mud puddle and saying, “The murkiness down there could just be routine automated guidance and control operations with robotic feedback software, and the squiggles could be gigabytes of storage area networks with rapid retrieval, but hey. Whatever. Oh, and there’s a maintenance crew that can swap out outboard motor blades on the fly, too. Stickagum, man?” Get the picture here, folks – these are cells that in Darwin’s day were thought to be made of undifferentiated blobs of jelly-like stuff. For lack of a better word to describe it, they called it by the suggestive pantheistic term, “protoplasm” (first living substance). Anybody who thinks that way now with what molecular biology has revealed should get 39 lashes with a wet flagellum. Evolution was missing from these papers because it is bankrupt. It thrived in another age, another time, when puffed-up, imperialistic, progress-minded Victorians didn’t know better. This is the information age. The only theory with the vocabulary, concepts and explanatory resources to deal with observations that are rich in engineering, machinery and control language is intelligent design.(Visited 23 times, 1 visits today)FacebookTwitterPinterestSave分享0
11 November 2004South African motorsport entered a new era this month with the launch of the A1 Grand Prix South African team. President Thabo Mbeki attended the launch and first track test at the Kyalami race track in Johannesburg on 1 November, unveiling the new car in its South African livery.The world of high-performance motor racing is set to be revolutionised by the establishment of A1 Grand Prix, which will oversee the World Cup of Motorsport. South Africa is heavily involved in the new competition, and will host an event in the inaugural six-race season.At the A1 Grand Prix launch in London in September, South Africa’s participation in the unique one-make series was announced along with that of China, Lebanon, Pakistan, Portugal and the UK. Since then, Australia, Canada and Malaysia have joined the A1 Grand Prix grid – with more countries soon to be announced.A1 Grand Prix CEO Sheikh Maktoum presented SA’s seat holder, businessman Tokyo Sexwale, with the car, saying South Africa was “a country that loves all sporting events, and I am certain as a nation it will be one of the most enthusiastic in supporting its A1 Grand Prix team and driver”.Sexwale, who said in London that the car would carry two numbers – Nelson Mandela’s prison number, 46664, and 2010, the year SA will host the Football World Cup – commented: “A1 Grand Prix is effectively the world cup of motor racing. It will create a new patriotic edge to the sport, and add a new dimension to one of the most popular sports in the world.”Sexwale said South Africa believed strongly in “the need to spread motor racing away from its traditional European and North American roots and into the developing world.“Welcome to the world of Motortainment.”Over 20 000 SA motorsport fans got to see the new car in action at Kyalami. After completing a series of demonstration laps around the 4.2 kilometre circuit, driver Alan van der Merwe said it was “incredible to drive this car in my own country and see the support from the fans.“I am very impressed with what the car is capable of, especially in terms of power and downforce … For me the chance to drive the car in the series would be amazing.”A test of driving skillsFormula One has long been the standard setter for ultimate motor racing, but it has been largely European-based. Many would complain that it has also become a battle of finances and technology, not a contest between top drivers competing in equally matched supercars.A1 Grand Prix aims to change all that. It wants to take world-class racing to previously unvisited territories – and the cars used in the competition will all be equal.“Each national team will drive a single type of high-performance car … ensuring a level playing field that will place driver skill at the heart of the competition”, the organisers say.Lola Cars International is building the cars – 30 are already on order – with new 3.4-litre V8 engines developed specifically for the new competition by Zytek Engineering.With the blessing of motorsport’s governing body, the Federation Internationale de l’Automobile (FIA), A1 Grand Prix’s World Cup of Motorsport will take place during Europe’s winter – after the completion of the Formula One season – starting in September 2005.The first season will feature races in Bahrain, Qatar, China, South Africa, Malaysia, and Australia, with the South African leg scheduled for Kyalami in December 2005.Independent research commissioned by A1 Grand Prix suggests it is a concept that could go far – and bring in big money for investors. Estimates are that there are over a quarter of a billion motorsport fans in the 24 countries targeted for the World Cup of Motorsport.New teams announced during the South Africa launch were 1980 F1 World Champion Alan Jones and Formula 3 team boss Alan Docking for Australia; Regent Mercantile Bancorp chairman J Jay Laski for Canada; and Formula 1 and USA Champ Car Series driver Alex Yoong for Malaysia.The identities of two major sporting figures representing Portugal’s seat holders were also revealed during the Johannesburg roadshow: football star Luis Figo and Real Madrid (and former South Africa) coach Carlos Queiros.Mandela’s blessingSheikh Maktoum, a member of Dubai’s Royal Family, is the founder of the series, and one of three men putting up the money for the ambitious project. The other two are South Africans Brian Menell and Tony Teixeira.During his SA trip, Maktoum, along with Menell and Teixeira, paid a visit to Nelson Mandela, who gave the new series his blessing, saying he supported the concept of a South African driver and team being able to compete on equal terms against other nations.“It was a real honour to meet with one of the world’s true iconic and historic figureheads”, Maktoum said. “His support for our championship and acceptance of our level playing field ideals is an endearing stamp of approval from such a symbolic person, which I humbly acknowledge.”The Sheikh hopes that A1 Grand Prix will become a rival to the monolithic empire of Formula One, run by Bernie Ecclestone. “Most of the stars currently in F1 were not well known before”, he commented. “I’m looking to create new stars.“We are going to have probably the first African driver in motorsport in A1 Grand Prix. We are going to have the first Indian driver in a blue-chip event. It’s an opportunity for these nations to shine.”SouthAfrica.info reporter Want to use this article in your publication or on your website?See: Using SAinfo material
Facebook Twitter Google+LinkedInPinterestWhatsAppMontego Bay, Jamaica, December 13, 2016 – Sandals Royal Bahamian Spa Resort and Offshore Island welcomed country music fans to the Caribbean December 8-11 for its second Story Behind the Songs concert event. In partnership with Big Machine Label Group, this installment of Story Behind the Songs featured top country music artists Eli Young Band and Tucker Beathard. As part of Sandals Resorts International’s new LIV+ Events program, offering vacationers unique limited-edition events, Sandals Resorts and Beaches Resorts teamed up with Premier Networks to host Story Behind the Songs, a new concert series showcasing a collection of intimate acoustic performances with top country artists.The second stop in the Caribbean for the Story Behind the Songs series was in the beautiful Nassau, Bahamas. The four-day getaway included live performances on Friday night with Grammy-nominated and ACM Award-winning chart-toppers, Eli Young Band, and a rocking opening performance by breakout singer/songwriter, Tucker Beathard. The musical events included backstories of each song told first-hand by the artists, from memories on the road to the inspiration behind the songs. This once in a lifetime opportunity was enjoyed by Sandals LIV+ vacationers, along with 30 lucky radio listeners who won their way to paradise by tuning into their favorite local country station or the nationwide contest on CMT After MidNite with Cody Alan, CMT All Access with Cody Alan, and CMT Radio Live with Cody Alan. The music carried from The Bahamas to the airwaves throughout the weekend as the artists met with 17 radio stations garnered by MicnE Productions. DJs and radio hosts caught up with the artists on air as the stations broadcasted live from the tropical Sandals Royal Bahamian Luxury Included® resort. As the official event host, award-winning country music personality Cody Alan also sat down with the Eli Young Band and Tucker Beathard as they shared their Story Behind the Songs experiences, including a red carpet Meet & Greet with fans, a VIP LIV+ Official Wrap Party with DeeJay Static and special presentation by the Sandals Foundation, the non-profit arm of Sandals Resorts International.In an effort to improve the lives of those in the Caribbean, proceeds from Story Behind the Songs t-shirt sales, silent auction and a portion of LIV+ package sales were donated to the Sandals Foundation’s Holiday effort. As a special thank you for the donations and in- kind Holiday Toys that will go to local children in The Bahamas, the local Rake & Scrape Band and school choir from Gerald Cash Primary School prepared a surprise musical performance, singing Eli Young Bands’ hit single, “Even If It Breaks Your Heart.”In total, the Story Behind the Songs event raised US $7,894 for the Sandals Foundation, of which 100% of the proceeds will go to benefit local community programs in the Caribbean. #MagneticMediaNews Related Items:#magneticmedianews Electricity Cost of Service Study among the big agenda items at September 11 Cabinet meeting ALERT # 2 ON POTENTIAL TROPICAL CYCLONE NINE ISSUED BY THE BAHAMAS DEPARTMENT OF METEOROLOGY THURSDAY 12TH SEPTEMBER, 2019 AT 9 PM EDT The Luxury of Grace Bay in Down Town Provo Recommended for you Facebook Twitter Google+LinkedInPinterestWhatsApp
West Ham United have reportedly completed the signing of Mesaque Dju on a free transfer from Benfica.The 19-year-old joins the Hammers on a free transfer from Portuguese outfit Benfica after agreeing terms on a three-and-a-half-year contract.Dju is regarded as a player for the future by West Ham and will initially link-up with the team’s Under-23 squad.He said, according to talkSPORT: “I know a lot about West Ham because it is a very big club in England and helps young players get to the first team.”Explaining the impact Joao Felix is causing in world football Tomás Pavel Ibarra Meda – September 13, 2019 There is a certain urgency that is getting noticed about Joao Felix’s development as a young star in the world of football right now.At…“I want this and I’m working for this. I want to help the team and I want to score a lot of goals for this team.”Meanwhile, West Ham striker Marko Arnautovic has committed his immediate future to the club after being linked with a move away.The Austria international was the subject of interest from teams in China, but has opted to stay with the Hammers until at least the end of the season.
More than one out of three Indians 36 per cent – share personal data or sensitive information using public Wi-Fi while travelling which can lead to data stealing, a study by Intel Security revealed on Tuesday. The ‘Digital Detox: Unplugging on Vacation’ study was conducted across 14 countries (including India) with 14,000 people to understand consumer behaviour when travelling. India leads the pack when it comes to sharing information online. “Through this survey, we wanted to raise awareness about the need to adopt safe digital habits and share security measures to prevent personal information from being compromised while travelling,” said Venkat Krishnapur, Head, R&D Operations, Intel Security’s India Development Centre, in a statement. Also Read – Add new books to your shelfNearly 37 per cent of Indians could not last a day on vacation without checking social media. This was second only to Japan (45 per cent) when compared globally. Majority of Indians (54 per cent) were not willing to leave their smart phone at home while on vacation. “Travelers can be targets for cybercriminals who count on human and device vulnerabilities to provide them with a point of access to consumers’ data and devices. They can gain access to sensitive information via unsecured smartphones, laptops and even wearables, while also collecting data from social channels,” the findings showed. Connecting to unprotected Wi-Fi and Bluetooth devices can expose personal information to a cybercriminal. One should be especially careful when exchanging payment information. “With this in mind, make sure to update your Bluetooth and Wi-Fi history by removing previously ‘remembered’ wireless networks, like ‘cafewifi,’” the study noted.Whether it’s your location or selfie, criminals are more able to monitor your whereabouts via social activity and take advantage of you when you have the weakest protection. The pervasive use of technology in our day-to-day lives and popularity of bring-your-own-device (BYOD) ties our personal and work lives more closely than ever before – especially on vacation. “This can puts travellers at risk as they share their personal/confidential information online,” the study noted.